By Robert Preidt
FRIDAY, Nov. 20, 2020 (HealthDay Information) — The antiviral drug remdesivir will not be advisable for hospitalized COVID-19 sufferers as a result of there is no proof that it reduces their want for air flow or improves their probabilities of survival, a World Well being Group panel stated Thursday.
Remdesivir is thought to be a possible remedy for extreme COVID-19 and is used to deal with hospitalized sufferers, however there’s uncertainty about its effectiveness. However, the U.S. Meals and Drug Administration accredited the drug to deal with hospitalized COVID-19 sufferers in October.
Within the new evaluation, the WHO panel of consultants analyzed information from 4 worldwide randomized trials that assessed a number of remedies for COVID-19 and included greater than 7,000 hospitalized COVID-19 sufferers.
The panel — which included 4 individuals who’ve had COVID-19 — concluded that remdesivir has no significant affect on the danger of demise or every other necessary affected person outcomes, equivalent to the necessity for mechanical air flow or how lengthy it takes for his or her situation to enhance.
The outcomes of the trials do not show that remdesivir has no profit. As a substitute, they supply no proof that the drug improves affected person outcomes, the panel defined in an article printed Nov. 19 within the BMJmedical journal.
Nonetheless, given the danger of serious hurt, the comparatively excessive price, and the calls for on well being care workers (remdesivir have to be given intravenously), their suggestion is acceptable, the panel stated.
The panel additionally stated they assist continued enrollment into trials evaluating the usage of remdesivir in COVID-19 sufferers, particularly to supply extra dependable proof for particular teams of sufferers.
The longer term use of remdesivir in treating COVID-19 sufferers is unclear, provided that it is unlikely to be the lifesaving drug many have hoped for, American journalist Jeremy Hsu wrote in a linked article within the journal.
He additionally famous that various remedies — equivalent to the cheap and broadly accessible corticosteroid dexamethasone, which has been proven to scale back demise threat in severely unwell COVID-19 sufferers — are actually a part of the discussions about remdesivir’s value as a COVID-19 remedy.
“It is turn out to be clear that remdesivir, at finest, has a marginal profit if any on medical enchancment,” stated Dr. Amesh Adalja, a senior scholar on the Johns Hopkins Heart for Well being Safety in Baltimore. “It’s not stunning, due to this fact, that the WHO guideline committee doesn’t assist its use, underscoring the necessity for higher remedies that extra meaningfully affect affected person outcomes.”
For extra on remedies for extreme COVID-19, go to the U.S. Centers for Disease Control and Prevention.
SOURCES: BMJ, information launch, Nov. 19, 2020; Amesh Adalja, MD, senior scholar, Johns Hopkins Heart for Well being Safety, Baltimore